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Forgotten driving forces in right heart failure (Part II): experimental study
Sayed Nour1, Gang Dai, Qinmei Wang
1Laboratory of Biosurgical Research, Pompidou Hospital, University Paris Descartes, Paris, France. nourmd@mac.com
Asian Cardiovascular & Thoracic Annals
|January 4, 2013
Summary
A novel pulsatile cardiac-assist device shows promise for acute right ventricular failure. This noninvasive method improved cardiac output and reduced pressures compared to current therapies.
Area of Science:
- Cardiovascular research
- Medical device innovation
- Hemodynamic support
Background:
- Right ventricular failure presents significant challenges in cardiac care.
- Existing cardiac-assist devices for right ventricular failure have shown limited success.
- This study investigates a novel pulsatile device as an alternative therapy.
Purpose of the Study:
- To evaluate the efficacy of a pulsatile cardiac-assist device in a porcine model of acute right ventricular failure.
- To compare the pulsatile device's performance against standard medical management.
- To assess hemodynamic parameters and physiological responses to the device.
Main Methods:
- Acute right ventricular failure was induced in 12 piglets via pulmonary regurgitation.
- Animals were randomized into two groups: pulsatile device (P) and non-pulsatile medical therapy (NP).
- Hemodynamic parameters, including cardiac output and pressures, were monitored. Western-blot analysis assessed nitric oxide synthase expression.
Main Results:
- The pulsatile device group (P) demonstrated significantly improved cardiac output compared to the non-pulsatile group (NP).
- Group P exhibited lower mean right ventricular and pulmonary arterial pressures.
- Pulmonary and systemic vascular resistance indices were substantially reduced in group P, with increased NO synthase expression.
Conclusions:
- The pulsatile suit is a safe, noninvasive option for acute right ventricular failure.
- This cost-effective, near-physiological approach is suitable for both adult and pediatric patients.
- The device offers a promising alternative to current treatments for right ventricular dysfunction.
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