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Updated: May 15, 2026
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Simultaneous lymph node involvement by Castleman disease and Kaposi sarcoma.
Luciana Wernersbach Pinto1, Estevão Portela Nunes
1Instituto de Pesquisa Clínica Evandro Chagas (IPE), Fiocruz Rio de Janeiro (RJ), Brazil.
Revista Brasileira De Hematologia E Hemoterapia
|January 4, 2013
Summary
Multicentric Castleman disease and Kaposi sarcoma, both Human herpesvirus 8 related, can co-occur in HIV patients. Immunohistochemistry for HHV-8-LANA-1 aids in diagnosing these concurrent conditions.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Multicentric Castleman disease (MCD) and Kaposi sarcoma (KS) are more prevalent in individuals with HIV infection.
- While both are Human herpesvirus 8 (HHV-8) related conditions, their co-occurrence within the same tissue is infrequently reported.
Purpose of the Study:
- To report a case of MCD in an HIV-infected patient.
- To highlight the concurrent presence of microscopic KS within the same lymph node during pathological examination.
Main Methods:
- Case report detailing pathological findings.
- Immunohistochemistry for Human herpesvirus 8-Latency Associated Nuclear Antigen 1 (HHV-8-LANA-1) expression was utilized.
Main Results:
- The study identified coexisting MCD and microscopic KS in a single lymph node from an HIV-positive patient.
- Immunohistochemistry confirmed the presence of HHV-8-LANA-1, supporting the diagnosis of both conditions.
Conclusions:
- The co-occurrence of MCD and KS in HIV-infected individuals is possible, though rare.
- Immunohistochemistry for HHV-8-LANA-1 is a valuable diagnostic tool for identifying these concurrent HHV-8-related lesions.
