Multiple myeloma with cells typically seen in storage diseases
Edmir Boturão Neto1, Mihoko Yamamoto, Yara Menezes
1Hematology and Transfusion Medicine Department, Universidade Federal de São Paulo - UNIFESP, São Paulo (SP), Brazil.
Revista Brasileira De Hematologia E Hemoterapia
|January 4, 2013
Summary
This study describes a rare multiple myeloma case featuring unusually large cancer cells with abundant azurophilic inclusions, a characteristic typically observed in storage diseases.
Area of Science:
- Hematology
- Oncology
- Cell Biology
Background:
- Multiple myeloma is a plasma cell malignancy.
- Azurophilic inclusions are typically associated with lysosomal storage disorders.
- Atypical presentations of multiple myeloma can pose diagnostic challenges.
Purpose of the Study:
- To report a rare case of multiple myeloma.
- To highlight the unusual cellular morphology observed in this case.
- To discuss the implications of azurophilic inclusions in myeloma cells.
Main Methods:
- Case report.
- Morphological analysis of myeloma cells.
- Review of relevant literature.
Main Results:
- A rare case of multiple myeloma was identified.
- Myeloma cells exhibited atypically large size.
- Abundant azurophilic inclusions were present within the myeloma cells.
- These inclusions resemble those seen in storage diseases.
Conclusions:
- This case expands the morphological spectrum of multiple myeloma.
- The presence of azurophilic inclusions in myeloma cells is highly unusual.
- Further investigation may be needed to understand the origin and significance of these inclusions.
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