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Related Experiment Video

Updated: May 15, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Task-dependent changes in cross-level coupling between single neurons and oscillatory activity in multiscale

Ryan T Canolty1, Karunesh Ganguly, Jose M Carmena

  • 1Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, California, USA.

Plos Computational Biology
|January 4, 2013
PubMed
Summary

Brain networks dynamically coordinate activity via neuronal oscillations, specifically the beta rhythm. This study reveals task-dependent changes in how neural activity maps to beta rhythm, suggesting a mechanism for brain network reorganization.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Understanding how functional brain networks dynamically coordinate activity is crucial in neuroscience.
  • Neuronal oscillations, particularly the beta rhythm (10-45 Hz), are hypothesized to play a key role in coordinating neural activity across different scales.
  • Previous research indicates that individual neuron spiking activity is coupled to the beta rhythm.

Purpose of the Study:

  • To investigate the role of the beta rhythm in dynamic coordination of neural ensembles during motor control.
  • To examine how the relationship between beta rhythm and neural spiking changes based on task demands and control method (manual vs. brain-machine interface).

Main Methods:

  • Recorded multi-unit and local field potential (LFP) activity from macaque motor areas using microelectrode arrays.

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Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
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Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

Related Experiment Videos

Last Updated: May 15, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

  • Monkeys performed a delayed center-out reach task under two conditions: manual control (MC) and brain-machine interface control (BC).
  • Analyzed the coupling between neuronal spiking activity and various aspects of the beta rhythm (power, phase, inter-hemispheric phase differences).

    • Main Results:

    • Confirmed that neuronal spiking is coupled to the beta rhythm during both MC and BC, with diverse coupling preferences among neurons.
    • Demonstrated that the mapping between beta rhythm and neuronal firing rate is reversible and task-dependent.
    • Observed instances where increased beta power led to increased spiking in MC but decreased spiking in BC, or phase shifts in firing.

    Conclusions:

    • Task-dependent changes in the beta-to-rate mapping are a significant factor in the transient functional reorganization of neural ensembles.
    • Dynamic remapping of oscillatory activity to spike rate and timing may be a fundamental mechanism for computation and communication in distributed brain networks.