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Related Experiment Video

Updated: May 15, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Vitamin D status and cause-specific mortality: a general population study.

Tea Skaaby¹, Lise Lotte Nystrup Husemoen, Charlotta Pisinger

¹Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark. tea.skaaby.01@regionh.dk

|January 4, 2013

Summary

Low vitamin D levels are linked to increased mortality from respiratory, digestive, and metabolic diseases. This suggests exploring non-cardiovascular and non-cancer causes for the vitamin D-mortality association.

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Last Updated: May 15, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

Endocrinology
Public Health
Epidemiology

Background:

Vitamin D deficiency is linked to higher all-cause mortality in observational studies.
The specific causes of death contributing to this association require further investigation.

Purpose of the Study:

To investigate the association between vitamin D status and cause-specific mortality.

Main Methods:

Analysis of 9,146 individuals from two population-based studies (Monica10 and Inter99).
Assessment of vitamin D status via serum 25-hydroxyvitamin D.
Cause of death data obtained from The Danish Register of Causes of Death until December 2009 (832 deaths, 10.3-year median follow-up).

Main Results:

Higher vitamin D levels (fourth quartile) significantly correlated with lower mortality from respiratory diseases (HR 0.26), digestive system diseases (HR 0.28), and endocrine, nutritional, and metabolic diseases (HR 0.21) compared to the lowest quartile.
Non-significant trends towards lower mortality were observed for mental/behavioral and nervous system diseases.
No significant association was found between vitamin D status and mortality from neoplasms or circulatory system diseases.

Conclusions:

The findings suggest that causes beyond cardiovascular disease and cancer may explain the inverse association between vitamin D status and mortality.
Further research should explore the role of vitamin D in mortality related to respiratory, digestive, and metabolic systems.