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Related Experiment Video

Updated: May 15, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Multiple systemic diseases complicated by bisphosphonate osteonecrosis: a case report.

Fabrizio Carini¹, Lorena Barbano, Vito Saggese

¹Research Professor, University of Milan-Bicocca, Monza (MB), Italy.

Annali Di Stomatologia

|January 4, 2013

Summary

Patients with multiple systemic conditions taking bisphosphonates face increased risks of complications, including osteonecrosis of the jaw (ONJ). Careful management by a specialist team is crucial for these patients undergoing dental procedures.

Keywords:

CTX bisphosphonate osteonecrosis oral surgery therapeutic approach

Related Experiment Videos

Last Updated: May 15, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Area of Science:

Oral and Maxillofacial Surgery
Oncology
Internal Medicine

Background:

Bisphosphonate-associated osteonecrosis of the jaw (ONJ) is a serious complication.
Multiple systemic conditions can exacerbate ONJ risks and complications.

Purpose of the Study:

To highlight the increased risk of complications in patients with systemic diseases and ONJ.
To emphasize the need for specialized dental management in these complex cases.

Main Methods:

A case report detailing mandibular necrosis in a patient with complex systemic conditions on oral bisphosphonates.

Main Results:

Systemic conditions and multiple medications (e.g., bisphosphonates, antithrombotics) can impair tissue healing.
Bisphosphonate use exceeding three years correlates with increased ONJ risk in complex systemic situations.

Conclusions:

Oral surgery can be contraindicated or require significant modification in patients with certain systemic diseases.
Multidisciplinary specialist collaboration is essential for managing patients on bisphosphonates with complex systemic conditions during all surgical phases.