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[Toxical research of Kudiezi injection in safety re-evaluation]

Zhi-Qiang Li1, Jun Zhan, Yan-Peng Chang

  • 1Shenyang Shuangding Pharmaceutical Co., Ltd., Shenyang 110179, China. Zhiqiang3390@yahoo.com.cn

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|January 5, 2013
PubMed
Abstract

Insights

Kudiezi injection showed no toxicity in mice, but repeated high doses in rats caused reversible liver and kidney damage. Local irritation occurred with long-term, high-dose use, advising medical guidance and site rotation for clinical safety.

Area of Science:

  • Pharmacology
  • Toxicology
  • Traditional Chinese Medicine

Context:

  • Kudiezi injection is a traditional Chinese medicine formulation.
  • Understanding its toxicological profile is crucial for safe clinical application.

Purpose:

  • To evaluate the toxic effects of Kudiezi injection in mice and rats.
  • To establish a safety basis for the clinical use of Kudiezi injection.

Summary:

  • Mice receiving frequent Kudiezi injections showed no adverse effects.
  • Rats administered high doses of Kudiezi injection for extended periods exhibited reversible hematological, biochemical, and histopathological changes, primarily affecting the liver and kidneys.
  • Local irritation, including hemorrhage, edema, and inflammation, was observed at injection sites.

Impact:

  • This study provides essential safety data for the clinical application of Kudiezi injection.
  • Findings suggest that while generally safe in mice, high-dose, long-term administration in rats warrants caution due to potential organ toxicity and local irritation.
  • Recommendations include medical supervision and rotation of injection sites to mitigate risks.

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