New insights in research about acute ischemic myocardial injury and inflammation
Anne Vincent1, Benoit Lattuca, Nolwenn Merlet
1CNRS, UMR-5203, Institut de Génomique Fonctionnelle, 141, rue de Cardonille - 34094 Montpellier Cedex 5 - France. anne.vincent@igf.cnrs.fr
Abstract:
Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.
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