Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bayesian inference for dynamic Q matrices and attribute trajectories in hidden Markov diagnostic classification models.

The British journal of mathematical and statistical psychology·2026
Same author

<i>Lepidium meyenii</i> Walpers Promotes the Regeneration of Salivary Gland and Prevents Xerostomia After Irradiation Injury.

Nutrients·2025
Same author

Psychometric Validation of the Cantonese Version of the Patient-Centered Primary Care Instrument for Multimorbid Patients in Hong Kong.

Journal of primary care & community health·2025
Same author

<i>Porphyromonas gingivalis</i> GroEL Accelerates Abdominal Aortic Aneurysm Formation by Induction of M1 Polarization in Macrophages.

International journal of molecular sciences·2025
Same author

Modified citrus pectin protects aortic dissection development involving macrophage pyroptosis.

Archives of biochemistry and biophysics·2025
Same author

Advances and Challenges of Tissue Vascular Scaffolds and Supercritical Carbon Dioxide Technology in Cardiovascular Diseases.

Tissue engineering and regenerative medicine·2025

Related Experiment Video

Updated: May 15, 2026

In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish
10:26

In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish

Published on: May 8, 2020

Graphene-based anticancer nanosystem and its biosafety evaluation using a zebrafish model.

Chen-Wei Liu1, Feng Xiong, Hui-Zhen Jia

  • 1Key Laboratory of Biomedical Polymers (The Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, China.

Biomacromolecules
|January 5, 2013
PubMed
Summary

This study presents a novel graphene-based nanosystem for efficient drug delivery. The developed system demonstrates sustained drug release and improved safety profiles for anticancer drugs like doxorubicin (DOX).

More Related Videos

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment
09:56

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment

Published on: April 30, 2019

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
04:53

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors

Published on: August 25, 2022

Related Experiment Videos

Last Updated: May 15, 2026

In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish
10:26

In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish

Published on: May 8, 2020

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment
09:56

Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment

Published on: April 30, 2019

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
04:53

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors

Published on: August 25, 2022

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Developing effective drug delivery systems is crucial for cancer therapy.
  • Graphene-based nanomaterials offer unique properties for drug loading and release.
  • Controlled release of anticancer drugs can improve efficacy and reduce side effects.

Purpose of the Study:

  • To develop and validate a graphene-based delivery nanosystem for effective drug loading and sustained release.
  • To investigate the impact of graphene oxide (GO) oxidation degree on nanosystem properties.
  • To evaluate the in vitro and in vivo performance of the developed nanosystems.

Main Methods:

  • Simultaneous integration of naphthalene-terminated PEG (NP) and anticancer drugs (curcumin or doxorubicin (DOX)) onto oxidized graphene (GO).
  • Characterization of self-assembled nanosystems using techniques like confocal microscopy.
  • In vitro cytotoxicity assays using HeLa cells and in vivo safety assessment in a zebrafish model.

Main Results:

  • The oxidation degree of GO significantly influenced drug loading efficiency and nanosystem stability.
  • Graphene-based nanoassemblies enhanced cellular entry of DOX compared to free DOX or micelles.
  • Sustained drug release was observed without initial burst release, and formulations showed high stability against surfactants.
  • DOX-loaded nanoassemblies exhibited significantly lower in vitro cytotoxicity than free DOX.
  • Curcumin-loaded nanosystems were rapidly excreted from zebrafish with no adverse effects on growth.

Conclusions:

  • A facile strategy for creating stable, biocompatible graphene-based drug delivery nanosystems was successfully developed.
  • These nanosystems demonstrate potential for enhanced anticancer drug delivery with improved safety profiles.
  • The findings support the advancement of graphene-based nanotherapeutics for biomedical applications.