Related Experiment Video

Updated: May 15, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
06:08

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

Investigation of the aortic pulse wave velocity in patients with Gilbert's syndrome

Erol Arslan1, Mustafa Çakar, Hakan Şarlak

  • 1Department of Internal Medicine, Gulhane Military Medical Academy , Ankara , Turkey.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|January 5, 2013
PubMed

Insights

Patients with Gilbert's syndrome exhibit lower arterial stiffness, measured by pulse wave velocity (PWV). Higher bilirubin levels in these patients correlate with reduced PWV, suggesting potential cardiovascular benefits.

Area of Science:

  • Cardiovascular Medicine
  • Hepatology
  • Genetics

Background:

  • Arterial stiffness, measured by aortic pulse wave velocity (PWV), is a key cardiovascular risk predictor.
  • Gilbert's syndrome is a genetic liver disorder causing elevated bilirubin, inversely linked to cardiovascular events.

Purpose of the Study:

  • To investigate serum bilirubin levels and arterial stiffness in Gilbert's syndrome patients.
  • To explore the relationship between bilirubin and cardiovascular parameters in this cohort.

Main Methods:

  • Compared PWV and serum bilirubin levels in 26 Gilbert's syndrome patients and 27 healthy controls.
  • Recorded routine blood chemistry and arterial stiffness measurements.

Main Results:

  • Gilbert's syndrome patients showed significantly lower PWV (6.68 m/s) than controls (7.3 m/s).
  • PWV correlated inversely with total and indirect bilirubin levels in Gilbert's syndrome patients (r = -0.370, P = .009; r = -0.495, P = .003).

Conclusions:

  • Gilbert's syndrome is associated with reduced arterial stiffness (lower PWV).
  • Bilirubin levels are linked to arterial stiffness in these patients.
  • Findings suggest a potential protective effect against atherosclerosis in Gilbert's syndrome.

More Related Videos

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Assessment of apical radial pulse01:25

Assessment of apical radial pulse

Apical-Radial (A-R) Pulse Assessment
The A-R pulse assessment involves simultaneous evaluation of the apical and radial pulses. When the apical and radial pulse rates vary, this assessment helps identify a pulse deficit.
Pre-Procedural Preparation
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Pulse01:16

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical indicator...