[Amoniuria, urinary gap and osmolal in patients with moderate renal insufficiency]

The chronic metabolic acidosis induces increase in the urinary ammonium production (NH4+u) like equalizer, reflected in major or measured minor, if the process is chronic or acute. The objective of the present work was to study the capacity of urinary acidification in patients with Failure Renal Chronic (FRC), stage II and III measuring NH4+u and to compare results with GAP urinary (GAPu), GAP urinary modified (GAPu mod), GAP Osmolal (GAPosm) and GAP Osmolal modified (GAPosm modif.) like indirect indices of amoniuria. Samples Venous/arterial blood and a draft fresh urine of 34 patients were analyzed. Statistically significant correlation was obtained (p < 0,003) between NH4+u ug/min/1.73m2 versus GAPu mmol/l (r = -0,4979) and GAPu mod mmol/l (- 0.5032), improving when NH4+u normatizó by creatinine (r = - 0.6793 and 0.6087 respectively, p < 0,0001). The GAPosm and GAPosm modif did not show significance at the time of evaluating NH4+u, contrary GAPu and GAPu mod would offer an indirect measurement of excretion of NH4+u, having given this last protein nutritional information. A value of p < 0.05 was considered statistically significant.