Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interfacial Redox Recycling Nanocatalysts with Ultrahigh Peroxidase Activity for Colorimetric Sensing Applications.

ACS applied nano materials·2026

Same author

Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders: The EXCALIBUR Study.

Journal of the American College of Cardiology·2026

Same author

Endothelial ACKR1 expression regulates neutrophil infiltration and breast cancer metastatic engraftment in the lung metastatic niche.

bioRxiv : the preprint server for biology·2026

Same author

Impact of Scan Location on Visualization Characteristics of the Lateral Rectus-Superior Rectus Band with High-Resolution Magnetic Resonance Imaging.

AJNR. American journal of neuroradiology·2026

Same author

Cardiopulmonary fitness in patients undergoing major hepato-pancreatobiliary surgery who are non-anaemic and iron replete vs. non-anaemic and iron deficient: an observational study.

Anaesthesia·2026

Same author

From infestation to infection: a systematic review of arthropod-mediated microbial transmission in hospitals.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026

Search research articles

Related Experiment Video

Updated: May 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Antiphospholipid-antibody-associated panniculitis.

Raegan D Hunt¹, Maria Robinson, Rishi Patel

¹The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.

Dermatology Online Journal

|January 5, 2013

Summary

A man with antiphospholipid syndrome experienced recurring skin nodules. Treatment with aspirin improved his condition, correlating with reduced antiphospholipid antibody levels.

More Related Videos

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Related Experiment Videos

Last Updated: May 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Dermatology
Rheumatology
Immunology

Background:

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by blood clots and pregnancy complications.
Cutaneous manifestations of APS are diverse, but panniculitis is less commonly reported.
This case highlights a potential link between specific antiphospholipid antibodies and inflammatory skin conditions.

Observation:

A 60-year-old male presented with recurrent, tender, erythematous leg nodules and arthralgias.
He had a history of incidentally discovered lupus anticoagulant antibodies.
Skin biopsy revealed septal and lobular panniculitis with eosinophils, fibrosis, and fat necrosis, but no vasculitis.

Findings:

Laboratory results showed an elevated activated partial thromboplastin time (PTT).
Significantly elevated anti-beta-2 glycoprotein I antibodies (IgM and IgG) and moderately elevated anticardiolipin antibodies (IgM and IgG) were detected.
The patient's skin condition correlated with fluctuations in antiphospholipid antibody levels.

Implications:

This case suggests a possible association between antiphospholipid antibodies and eosinophilic panniculitis.
Aspirin therapy demonstrated efficacy in managing both the skin lesions and potentially modulating antibody levels.
Further research is warranted to elucidate the pathogenic mechanisms linking antiphospholipid antibodies to panniculitis and explore targeted therapeutic strategies.