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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Anetoderma secondary to antiphospholipid antibodies
John Eungdamrong1, Max Fischer, Rishi Patel
1The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.
Dermatology Online Journal
|January 5, 2013
Summary
Anetoderma, a skin condition, can indicate the presence of antiphospholipid antibodies (APAs). Further investigation for connective-tissue disorders is recommended for patients with this finding.
Area of Science:
- Dermatology
- Immunology
- Rheumatology
Background:
- Anetoderma is an elastolytic disorder linked to various autoimmune and infectious conditions.
- Understanding the association between anetoderma and autoimmune markers is crucial for diagnosis.
Observation:
- A case study involving a patient with generalized anetoderma revealed positive antinuclear antibodies and antiphospholipid antibodies (APAs).
Findings:
- Literature suggests anetoderma may be a specific indicator of APAs.
- This association exists with or without systemic lupus erythematosus or antiphospholipid syndrome manifestations.
Implications:
- Patients presenting with anetoderma should be evaluated for underlying connective-tissue disorders.
- Early workup can lead to timely diagnosis and management of associated autoimmune conditions.
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