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Fox-Fordyce disease.

John Yost1, Maria Robinson, Shane A Meehan

  • 1The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.

Dermatology Online Journal
|January 5, 2013
PubMed
Summary
This summary is machine-generated.

Fox-Fordyce disease (FFD) is a rare inflammatory skin condition affecting apocrine glands. Current treatments are challenging, with gland removal being effective for refractory cases.

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Area of Science:

  • Dermatology
  • Pathophysiology

Background:

  • Fox-Fordyce disease (FFD) is a rare inflammatory disorder impacting apocrine sweat glands.
  • Its etiology is unclear, but hormonal influences are suspected due to higher prevalence in women and symptom fluctuations with hormonal changes.

Observation:

  • FFD presents as uniform, firm, folliculocentric papules, typically in the axillae, anogenital region, and other areas with apocrine glands.
  • Histopathology reveals apocrine duct obstruction by hyperkeratotic plugs, leading to ductal rupture and inflammation.

Findings:

  • Treatment for FFD is difficult, with no single agent proving universally effective.
  • First-line treatments include topical and interlesional glucocorticoids, though limited by atrophy concerns.
  • Other treatments like retinoids, antibiotics, and oral contraceptives show some success; surgical removal of apocrine glands is effective for refractory cases.

Implications:

  • Further research into FFD's pathophysiology may reveal more targeted treatment options.
  • Understanding hormonal influences could lead to novel therapeutic strategies.
  • Effective management of FFD, especially refractory cases, can significantly improve patient quality of life.