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[A case of amineptine dependence].

J C Pérez de los Cobos1, L L Jorda, C Pelegrin

  • 1Hospital Ramòn y Cajal, Servicio de Psiquiatria, Madrid, Espagne.

L'Encephale
|January 1, 1990
PubMed
Summary

This case study details amineptine (Survector) dependence in a patient with prior amphetamine dependence. The patient developed anxiety upon discontinuing high-dose amineptine, highlighting risks associated with this antidepressant.

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Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Amineptine (Survector) is an antidepressant.
  • Previous amphetamine dependence is a relevant comorbidity.

Observation:

  • A patient with a history of amphetamine dependence developed amineptine dependence.
  • The patient self-administered high doses (3g/day) of amineptine to combat asthenia and maintain activity.
  • Anxiety symptoms emerged 48 hours after abrupt cessation of amineptine.

Findings:

  • This case highlights the potential for amineptine dependence, particularly in individuals with a history of substance abuse.
  • The patient's high-dose self-administration suggests a pattern of misuse to manage asthenia and activity levels.
  • Withdrawal symptoms, including anxiety, occurred upon discontinuation.

Implications:

  • Clinicians should exercise caution when prescribing amineptine, especially to patients with a history of substance dependence.
  • Careful monitoring and patient education are crucial to prevent misuse and dependence.
  • Further research into the neurobiological mechanisms of amineptine dependence is warranted.

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