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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
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Updated: May 15, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

[Prolonged corticosteroid therapy and diet].

C Le Jeunne1, E Aslangul

  • 1Service de médecine interne, université Paris Descartes, Hôtel-Dieu AP-HP, 1, place du Parvis-de-Notre-Dame, 75004 Paris, France. claire.le-jeunne@htd.aphp.fr

La Revue De Medecine Interne
|January 5, 2013
PubMed
Summary
This summary is machine-generated.

Glucocorticoid treatments require dietary changes like low salt and high protein. However, current practices often only include salt restriction and calcium/vitamin D supplements, with limited research on other measures.

Related Experiment Videos

Last Updated: May 15, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Area of Science:

  • Endocrinology and Nutrition
  • Pharmacology

Context:

  • Long-term glucocorticoid therapy is associated with significant adverse effects.
  • Dietary interventions are recommended to mitigate these side effects.
  • Current clinical practice often involves simplified dietary recommendations.

Purpose:

  • To review the recommended dietary measures for patients undergoing long-term glucocorticoid treatment.
  • To assess the existing literature supporting these specific dietary interventions.
  • To identify gaps in research regarding the efficacy of comprehensive dietary management.

Summary:

  • Strict adherence to all recommended dietary measures (low salt, low glucose, high protein, low calorie, adequate potassium, calcium, and vitamin D3) is challenging.
  • Commonly adopted practices include salt restriction and calcium/vitamin D supplementation.
  • The scientific literature supporting these comprehensive dietary strategies is surprisingly limited, despite the long-standing use of glucocorticoids.

Impact:

  • Highlights the need for more research into optimal dietary strategies for glucocorticoid users.
  • Suggests that current dietary recommendations may be insufficient or incompletely supported by evidence.
  • Emphasizes the importance of evidence-based nutritional guidance in managing long-term medication side effects.