Related Experiment Video

Updated: May 15, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy

Milos Kubanek1, Marek Sramko, Jana Maluskova

  • 1Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. milos.kubanek@ikem.cz

Journal of the American College of Cardiology
|January 5, 2013
PubMed

Insights

Cardiac MRI and B-type natriuretic peptide (BNP) levels effectively predict left ventricular reverse remodeling (LVRR) in recent-onset dilated cardiomyopathy (DCM). These methods offer superior prognostication compared to endomyocardial biopsy and conventional tests.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomarkers

Background:

  • Left ventricular reverse remodeling (LVRR) signifies a positive prognosis in recent-onset dilated cardiomyopathy (DCM).
  • Novel prognostic methods are crucial for predicting LVRR in DCM patients.

Purpose of the Study:

  • To assess the predictive performance of cardiac magnetic resonance (CMR), cardiac biomarkers, and endomyocardial biopsy (EMB) for LVRR in recent-onset DCM.
  • To compare the efficacy of CMR, biomarkers, and EMB against conventional methods in predicting LVRR.

Main Methods:

  • 44 patients with recent-onset DCM underwent baseline CMR, biomarker measurements (including B-type natriuretic peptide - BNP), and EMB.
  • Cardiopulmonary exercise testing and echocardiography were also performed.
  • CMR and BNP were reassessed at 12 months, with BNP also measured at 3 and 6 months. LVRR was defined by specific improvements in ejection fraction and left ventricular dimensions.

Main Results:

  • LVRR occurred in 45% of patients at 12 months.
  • Baseline CMR findings, specifically lower late gadolinium enhancement and higher myocardial edema ratio, independently predicted LVRR.
  • The strongest predictor of LVRR at 3 months was the BNP plasma level.

Conclusions:

  • Cardiac magnetic resonance (CMR) and serial B-type natriuretic peptide (BNP) testing are superior predictors of LVRR in recent-onset DCM.
  • These advanced methods outperform endomyocardial biopsy (EMB) results, other biomarkers, and conventional follow-up approaches for predicting LVRR.
Abstract

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...