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Related Experiment Video

Updated: May 15, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Environmental risk factors in systemic sclerosis.

Paula Dospinescu¹, Gareth T Jones, Neil Basu

¹Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, UK.

Current Opinion in Rheumatology

|January 5, 2013

Summary

Occupational silica and organic solvent exposures are linked to systemic sclerosis (SSc) development. While evidence is limited, further research may guide prevention strategies for this autoimmune disease.

Area of Science:

Environmental Medicine
Rheumatology
Occupational Health

Background:

Systemic sclerosis (SSc) pathogenesis is increasingly linked to environmental risk factors.
Understanding these exposures is crucial for managing this complex autoimmune condition.

Purpose of the Study:

To review current evidence on environmental risk factors implicated in systemic sclerosis (SSc).
To highlight occupational and non-occupational exposures potentially contributing to SSc development and severity.

Main Methods:

Literature review of studies investigating environmental exposures and systemic sclerosis.
Analysis of evidence related to silica, organic solvents, and other occupational agents.
Evaluation of non-occupational factors such as smoking and silicone implants.

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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

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Published on: March 24, 2017

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Last Updated: May 15, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Main Results:

Silica exposure is a primary occupational risk factor for SSc.
Emerging evidence suggests organic solvents may also contribute to SSc development.
Smoking impacts SSc severity but not disease development; silicone implants lack proven association.

Conclusions:

Environmental exposures, particularly occupational ones, are likely significant in SSc development.
Current evidence is based on heterogeneous studies with small sample sizes.
Multicenter collaborations are needed to strengthen findings and inform prevention.