Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repetitive Pressure Overload; Species Disparities, Mechanisms and Translational Relevance.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Modifying the structural substrate and progression of heart failure with preserved ejection fraction using a regular exercise regimen in pigs.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Thoracic Aortic Aneurysm Development Is Dependent on Membrane Type-1 Matrix Metalloproteinase Activity and Abundance.

Biomolecules·2026
Same author

Soluble cytokine receptor levels in obstructive sleep apnea patients treated with continuous positive airway pressure therapy.

Future science OA·2026
Same author

Psychological stress and myocardial extracellular matrix remodeling- a pathologic synergy.

Biochemical pharmacology·2026
Same author

Correction to "Hydrophilic Coating Microstructure Mediates Acute Drug Transfer in Drug-Coated Balloon Therapy".

ACS applied bio materials·2026

Related Experiment Video

Updated: May 15, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Membrane-associated matrix proteolysis and heart failure.

Francis G Spinale1, Joseph S Janicki, Michael R Zile

  • 1Cardiovascular Translational Research Center, CBA, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC, USA. cvctrc@uscmed.sc.edu

Circulation Research
|January 5, 2013
PubMed
Summary

Matrix metalloproteinases (MMPs) play a complex role in heart remodeling. Unexpected MMP activity in left ventricle remodeling may drive adverse changes, offering new therapeutic targets for heart failure.

More Related Videos

Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

Related Experiment Videos

Last Updated: May 15, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

Area of Science:

  • Cardiovascular Biology
  • Extracellular Matrix Research
  • Protease Biochemistry

Background:

  • The extracellular matrix (ECM) is crucial for myocardial structure and function.
  • Alterations in ECM integrity and activity contribute to heart remodeling.
  • Matrix metalloproteinases (MMPs) are key ECM enzymes implicated in heart failure progression.

Purpose of the Study:

  • To investigate the evolving understanding of MMP roles in left ventricle remodeling.
  • To highlight surprising findings regarding MMP profiles in various cardiac stress conditions.
  • To explore the potential of MMPs as therapeutic targets in adverse cardiac remodeling.

Main Methods:

  • Review of recent clinical and basic research on MMPs in left ventricle remodeling.
  • Analysis of changes in MMP expression and activity patterns.
  • Examination of MMP-mediated proteolytic processing of signaling molecules.

Main Results:

  • MMP profiles in left ventricle remodeling show unexpected changes under pressure/volume overload and myocardial infarction.
  • Certain MMPs, especially transmembrane MMPs, facilitate ECM accumulation.
  • MMPs modulate fibroblast transdifferentiation, a key event in adverse remodeling.

Conclusions:

  • MMPs have a complex, sometimes counterintuitive, role in left ventricle remodeling.
  • Proteolytic processing by MMPs can promote adverse ECM accumulation and fibroblast changes.
  • Further research into MMPs and ECM remodeling may reveal novel therapeutic strategies for heart failure.