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Related Experiment Video

Updated: May 15, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Nanoparticle delivery enhancement with acoustically activated microbubbles.

Lee B Mullin1, Linsey C Phillips, Paul A Dayton

  • 1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University-UNC-NCSU, Chapel Hill, NC, USA.

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
|January 5, 2013
PubMed
Summary
This summary is machine-generated.

Microbubbles and ultrasound enhance nanoparticle delivery by increasing permeability for drugs and genes. This review covers mechanisms, techniques, nanoparticle types, and the benefits and limitations of this approach.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Microbubbles and ultrasound are increasingly used for targeted nanoparticle delivery.
  • Ultrasound exposure enhances nanoparticle transport by increasing cellular and vascular permeability.

Purpose of the Study:

  • To review the mechanisms and techniques for ultrasound- and microbubble-mediated nanoparticle delivery.
  • To discuss current preclinical nanoparticle investigations, and the advantages and disadvantages of this delivery system.

Main Methods:

  • Literature review of studies on microbubble- and ultrasound-enhanced nanoparticle delivery.
  • Analysis of mechanisms, delivery techniques, and nanoparticle types.
  • Evaluation of limitations and benefits of the microbubble-based approach.

Main Results:

  • Ultrasound and microbubbles significantly improve nanoparticle delivery efficiency.
  • Various nanoparticle types are under investigation for preclinical applications.
  • The approach offers benefits in targeted delivery but has limitations to address.

Conclusions:

  • Microbubble- and ultrasound-mediated delivery is a promising strategy for drug and gene therapy.
  • Further research is needed to optimize techniques and overcome existing limitations for clinical translation.