Related Experiment Videos
Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria
T Yamamoto1, H Sugawara, S Shimizu
1Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
The International Journal of Biochemistry
|January 1, 1990
Abstract:
1. The existence of an intermediate pool of ubiquinone in intact mitochondria of rat heart was investigated. 2. The incorporation of [3H-methyl]S-adenosylmethionine into ubiquinone-9 was not influenced by the co-synthesis of the intermediate, 3-nonaprenyl-4-hydroxybenzoate. 3. In the intermediate-depleted mitochondria, the synthetic rate of the intermediate, 3-nonaprenyl-4-hydroxybenzoate was similar to that of ubiquinone. 4. The possible existence of 3-nonaprenyl-4-hydroxybenzoate as a metabolic pool under physiological condition is discussed.