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[Extracorporeal lithotripsy in experimental vesicular lithiasis in pigs]
R Capdeville1, J André-Bougaran, F Barrat
1Service de Radiologie, Centre Médico-Chirurgical de la Porte de Choisy, Paris.
Gastroenterologie Clinique Et Biologique
|January 1, 1990
Summary
Extracorporeal shock wave lithotripsy effectively fragmented gallstones in pigs. Lower frequencies achieved stone clearance without significant gallbladder damage, suggesting safe human application.
Area of Science:
- Gastroenterology
- Urology
- Biomedical Engineering
Context:
- Gallstones (biliary calculi) pose a significant health burden, necessitating effective and minimally invasive treatment options.
- Extracorporeal shock wave lithotripsy (ESWL) is a non-invasive modality for stone fragmentation.
- Evaluating the efficacy and safety of piezoelectric lithotripters for gallstone treatment is crucial.
Purpose:
- To assess the efficacy of the EDAP LT 01 piezoelectric lithotripter in fragmenting gallstones.
- To evaluate the safety profile of ESWL on the gallbladder and adjacent organs in a porcine model.
- To determine optimal lithotripsy parameters for gallstone treatment.
Summary:
- Experimental gallstone fragmentation was performed using the EDAP LT 01 piezoelectric lithotripter in pigs.
- Complete fragment clearance was observed in 60% of cases within 18 days post-procedure.
- Higher firing frequencies (40, 20 shots/sec) led to gallbladder perforation, while lower frequencies (≤10 shots/sec) resulted in mild, transient histological changes without organ damage.
Impact:
- Low-frequency ESWL demonstrates potential as a safe and effective method for gallstone treatment in humans.
- The study provides evidence for the clinical applicability of piezoelectric lithotripsy in managing biliary calculi.
- Findings guide the selection of appropriate lithotripsy parameters to minimize adverse events.