Antiglycative effect of fruit and vegetable seed extracts: inhibition of AGE formation and carbonyl-trapping

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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Marta Mesías1, Marta Navarro, Vural Gökmen

  • 1Institute of Food Science, Technology and Nutrition, ICTAN-CSIC, E-28040, Madrid, Spain. mmesias@ictan.csic.es

Journal of the Science of Food and Agriculture
|January 5, 2013
PubMed
Abstract

Insights

Fruit and vegetable seed extracts show significant anti-glycation activity, helping to prevent advanced glycation end-product (AGE) formation. These natural extracts offer a promising approach for mitigating AGE-related health complications.

Area of Science:

  • Food Science
  • Biochemistry
  • Gerontology

Background:

  • Advanced glycation end-products (AGEs) result from non-enzymatic glycation and contribute to diabetes and aging complications.
  • Mitigating AGE formation is crucial for addressing age-related pathologies.

Purpose of the Study:

  • To evaluate the antiglycative activities of eight aqueous fruit and vegetable seed extracts.
  • To identify specific extracts with potent AGE inhibition properties.

Main Methods:

  • Assessed antiglycative activity using protein-glucose and protein-methylglyoxal assays.
  • Determined the capacity of extracts to trap 1,2-dicarbonyls.
  • Quantified antioxidant and phenolic compound content.

Main Results:

  • All eight seed extracts demonstrated anti-AGE activity, with inhibition ranging from 20-92% (protein-glucose assay).
  • Green pepper extract showed the highest activity in the protein-glucose assay.
  • Peach and pomegranate extracts were most effective against methylglyoxal-induced AGEs (0-79% inhibition).
  • Apricot and peach extracts effectively inhibited AGE formation by trapping 1,2-dicarbonyls (IC50=0.14 mg mL(-1)).
  • No correlation was found between antioxidant/phenolic content and antiglycative activity, suggesting other hydrophilic compounds are involved.

Conclusions:

  • Aqueous fruit and vegetable seed extracts possess antiglycative properties.
  • These extracts can be utilized for preventing complications associated with AGEs in age-related diseases.

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