Related Experiment Video
Updated: Jan 25, 2026
05:18
Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
Published on: January 16, 2026
5
Advanced heart failure: transplantation, LVADs, and beyond
1FACC, Kaufman Center for Heart Failure, Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA. starlir@ccf.org
Cleveland Clinic Journal of Medicine
|January 5, 2013
Summary
Mechanical circulatory assist devices offer good outcomes for advanced heart failure patients when donor hearts are scarce. These devices serve as a bridge to transplant or as destination therapy, enhancing patient quality of life.
Area of Science:
- Cardiology
- Medical Devices
- Heart Failure Management
Background:
- Advanced heart failure presents a significant clinical challenge due to limited donor heart availability for transplantation.
- Heart transplantation offers good outcomes but faces donor organ shortages, necessitating alternative treatment strategies.
Purpose of the Study:
- To evaluate the role and efficacy of mechanical circulatory assist devices in managing advanced heart failure.
- To highlight the utility of these devices as a bridge to transplantation or as definitive "destination therapy".
Main Methods:
- Review of current literature and clinical data on mechanical circulatory assist devices.
- Analysis of patient outcomes and quality of life improvements in recipients.
Main Results:
- Mechanical circulatory assist devices have emerged as a viable and effective option for patients with advanced heart failure.
- These devices demonstrate significant improvements in quality of life for eligible patient candidates.
Conclusions:
- Mechanical circulatory assist devices are crucial in addressing the unmet needs of advanced heart failure patients.
- Consideration of these devices for bridge-to-transplant or destination therapy is strongly recommended for improving patient prognosis and well-being.
Related Concept Videos
01:22Heart Failure VI: Adjunct Therapies
292
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
292
01:30Heart Failure V: Medical Management
242
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
242
01:29Heart Failure II: Pathophysiology
822
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
822
01:27Heart Failure I: Introduction
757
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
757
01:17Pathophysiology of Heart Failure
3.2K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.2K
01:22Heart Failure Drugs: Diuretics
862
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
862