[Interaction of vasotonic bioeffectors in endothelial dysfunction pathogenesis due to arterial hypertension on aging]

One of the earliest impairments of target-organs due to arterial hypertension (AH) dysfunction is considered. The interrelation between AH and expressiveness of endothelial dysfunctions (ED) degree in the involutive changed vessels is defined. Features of mutual relation vasotonic bioeffectors--oxyde nitrogen (NO) and endothelin-1 (ET-1), interfaced to results of endothelial vasodilation are designated. The technique estimating epy degree of interaction between NO and ET-1 is offered. It is established, that against inertness vasodilation, developing under the combination of involutive and hypertensive damages, maintaining adequate blood flow in the vessel after the mechanical stress induced impact is provided at the expense of increase of speed of systolic and diastolic blood flow, improve the sensitivity of the endothelium to pressure of shift, change the synthesis and secretion of ET-1 and NO.