Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Chronic autoimmune thyroiditis as a predictor and precursor of metaplasia].

Klinicheskaia meditsina·2015
Same author

[Hypoparathyroidism and syndrome of hypocalcemia].

Klinicheskaia meditsina·2003
Same author

[Diagnosis and treatment of mineral corticism].

Klinicheskaia meditsina·2001
Same author

[Mineral corticism syndrome: classification, etiology and pathogenesis].

Klinicheskaia meditsina·2001
Same author

[Current views on pheochromocytoma].

Terapevticheskii arkhiv·1999
Same author

[Osteoporosis].

Klinicheskaia meditsina·1997
Same journal

[Impact of intravascular ultrasound on revascularization strategy modification in elderly patients with non-ST-segment elevation acute coronary syndrome undergoing unprotected left main coronary artery stenting.]

Advances in gerontology = Uspekhi gerontologii·2026
Same journal

[The effect of long-term exposure to essential oils on the psychoemotional state and mental performance of elderly people.]

Advances in gerontology = Uspekhi gerontologii·2026
Same journal

[Catecholaminergic structures of the human pineal gland.]

Advances in gerontology = Uspekhi gerontologii·2026
Same journal

[The role of lipid metabolism disorders in the activation of cellular aging markers in atherosclerosis in elderly and senile individuals.]

Advances in gerontology = Uspekhi gerontologii·2026
Same journal

[OCT-derived retinal and choroidal parameters as markers of aging: Association with biological age in healthy adults (RussAge Study).]

Advances in gerontology = Uspekhi gerontologii·2026
Same journal

[Age-related features of postural control among elderly women with fear of falling.]

Advances in gerontology = Uspekhi gerontologii·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

[Senile osteodystrophy].

V S Luk'ianchikov

    Advances in Gerontology = Uspekhi Gerontologii
    |January 8, 2013
    PubMed
    Summary
    This summary is machine-generated.

    This study examines the causes and development of bone diseases in older adults, proposing a new classification and analyzing osteoporosis prevention and treatment effectiveness.

    More Related Videos

    Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
    05:55

    Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

    Published on: September 27, 2024

    Related Experiment Videos

    Last Updated: May 15, 2026

    The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
    03:52

    The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

    Published on: February 21, 2025

    Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
    05:55

    Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

    Published on: September 27, 2024

    Area of Science:

    • Gerontology
    • Orthopedics
    • Pathology

    Context:

    • Osteodystrophy affects middle-aged and elderly populations.
    • Existing classifications may not fully capture the spectrum of bone diseases.
    • Senile bone disease, specifically systemic osteoporosis, is a major health concern in aging individuals.

    Purpose:

    • To explore the etiology and pathogenesis of major osteodystrophy forms in older adults.
    • To introduce a novel working classification for joint and bone diseases.
    • To conduct a meta-analysis on the efficacy of current osteoporosis prevention and treatment strategies.

    Summary:

    • The article investigates the origins and progression of common osteodystrophies in the elderly.
    • A new classification system for skeletal disorders is presented.
    • A meta-analysis evaluated the effectiveness of modern interventions for systemic osteoporosis.

    Impact:

    • Provides a refined understanding of age-related bone diseases.
    • Offers a new framework for classifying joint and bone conditions.
    • Informs evidence-based strategies for managing and preventing osteoporosis in the elderly.