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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...

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Related Experiment Video

Updated: May 15, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Hyperthermia-induced drug targeting.

Jonathan P May1, Shyh-Dar Li

  • 1Ontario Institute for Cancer Research, Drug Delivery and Formulation Group, Medicinal Chemistry Platform, Toronto, ON, M5G 0A3, Canada.

Expert Opinion on Drug Delivery
|January 8, 2013
PubMed
Summary
This summary is machine-generated.

Temperature-sensitive liposomes (TSLs) enable targeted drug delivery to tumors when combined with hyperthermia. Advanced imaging, like magnetic resonance-guided focused ultrasound, enhances this approach for precise cancer therapy.

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Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
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Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

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Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
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Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Targeted drug delivery is crucial for effective cancer therapy, minimizing systemic side effects.
  • Temperature-sensitive liposomes (TSLs) encapsulate drugs, releasing them specifically at tumor sites when exposed to heat.
  • ThermoDox® represents an advancement in TSLs, improving drug release and uptake in hyperthermia-treated tumors (around 41°C).

Purpose of the Study:

  • To review hyperthermia-induced drug delivery, focusing on TSL development and application in cancer therapy.
  • To discuss advanced image-guided heating technologies for TSL-based treatments.
  • To highlight real-time monitoring and efficacy prediction in drug delivery.

Main Methods:

  • Discussion of temperature-sensitive liposomes (TSLs) for drug delivery.
  • Integration of mild and ablative hyperthermia in cancer treatment strategies.
  • Presentation of image-guided heating technologies, including magnetic resonance-guided focused ultrasound (MRgFUS).

Main Results:

  • TSLs combined with hyperthermia show promise for targeted drug delivery.
  • MRgFUS enables localized chemotherapy with simultaneous drug release quantification.
  • Real-time monitoring and efficacy prediction are key aspects of advanced image-guided heating.

Conclusions:

  • Combining hyperthermia with TSLs demonstrates significant clinical potential for targeted cancer drug delivery.
  • The increasing use of image-guided focused ultrasound will further enhance the precision and efficacy of this approach.
  • Future research is expected to focus on multifunctional TSLs for even greater therapeutic benefits.