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Regulation of Metabolism

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...

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Related Experiment Video

Updated: May 15, 2026

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Published on: December 26, 2019

Metabolic makeover for HSCs.

Matthew R Warr¹, Emmanuelle Passegué

¹The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Medicine, Hematology/Oncology Division, University of California at San Francisco, San Francisco, CA 94143, USA.

|January 8, 2013

Summary

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation by switching metabolic programs. Distinct metabolic pathways support HSC quiescence and activation for blood cell production.

Area of Science:

Hematology
Stem Cell Biology
Metabolic Regulation

Background:

Hematopoietic stem cells (HSCs) are crucial for maintaining blood cell populations throughout life.

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Analysis of Hematopoietic Stem Progenitor Cell Metabolism

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Last Updated: May 15, 2026

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Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer

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HSCs exist in a quiescent state but must activate to proliferate and differentiate.

Understanding HSC regulation is vital for treating blood disorders and improving regenerative medicine.