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Steroidal glycolipid, L-644,257, is a potent enhancer of nonspecific host resistance
W K Hagmann1, M M Ponpipom, J J Jackson
1Department of Medicinal Chemical Research, Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.
International Journal of Immunopharmacology
|January 1, 1990
Abstract:
A steroidal glycolipid that enhances the nonspecific cellular response to opportunistic infection in an immunocompromised host has been discovered. A dose dependent response with 6-(5-cholesten-3 beta-yloxy)hexyl 1-thio-beta-D-mannopyranoside, L-644,257, was observed against several infective agents including bacterial, fungal, and viral pathogens in cyclophosphamide-treated mice. A mechanism for this protective action is proposed.