A genome-wide association study of depressive symptoms

Karin Hek¹, Ayse Demirkan¹, Jari Lahti¹+83

• ¹Research Centre O3 (KH, CLM, HT), Department of Psychiatry, and Department of Epidemiology (KH, AH, MK, AGU, HT), Erasmus MC, Rotterdam, The Netherlands; Institute of Behavioural Sciences (JL, KRa), University of Helsinki, Helsinki, Finland; Clinical Research Branch (TT), National Institute on Aging, Baltimore, Maryland; Interfaculty Institute for Genetics and Functional Genomics (ATeu), University Medicine Greifswald, Greifswald, Germany; Department of Nutrition (MCC, FBH, EBR, MKJ), Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology (EB, AVD-R, SK), University of Michigan School of Public Health, Ann Arbor, Michigan; Institute of Epidemiology II (JB, RE, K-HL), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Internal Medicine (JD), Division of Geriatrics, and Department of Epidemiology and Prevention (YL), Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina; Department of Medicine (KM), Cardiovascular Health Research Unit, University of Washington, Seattle, Washington; National Institute on Aging (ATer, OM, ARS), National Institutes of Health, Department of Health and Human Services, Baltimore; and Laboratory of Neurogenetics (MAN, ABS), Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland; Department of Epidemiology (YVS), Emory University, Atlanta, Georgia; EMGO Institute for Health and Care Research (NV, BPe), and Department of Psychiatry (NV, BPe), VU University Medical Center, Amsterdam, The Netherlands; Rush Alzheimer's Disease Center (LY, DAB), and Department of Neurological Sciences (LY, DAB), Rush University Medical Center, Chicago, Illinois; Geriatric Unit Azienda Sanitaria di Firenze (SB), Firenze, Italy; National Heart, Lung, and Blood Institute's Framingham Heart Study (EJB, MK-H, JMM, KLL, JM), Framingham; and Department of Medicine (EJB), Section of Cardiology and Preventive Medicine, Boston University School of Medicine and Public Health, Boston, Massachusetts; Department of Biological Psychology (DB, EdG), VU University, Amsterdam, The Netherlands; Istituto di Ricerca Genetica e Biomedica (AC, AMul, FC), Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy; Division of Public Health Sciences (LHC), Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Neurology (PLDJ), Program in Translational NeuroPsychiatric Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston; Department of Psychiatry (SP), Massachusetts General Hospital and Harvard Medical School, Boston, and the Broad Institute, Cambridge; and Department of Epidemiology (FBH, EBR), Harvard School of Public Health, Boston, Massachusetts; Department of Biostatistics (KRi), University of Washington, Seattle, Washington; Center of Biostatistics and Department of Medicine (ADP), University of Mississippi Medical Center, Jackson, Mississippi; Medical Genetics Institute (JIR), Cedars Sinai Medical Center, Los Angeles, California; Division of Cardiology (NS), and Cardiovascular Health Research Unit (NS), Department of Medicine, University of Washington, Seattle, Washington; National Institute for Health and Welfare (JGE); Department of General Practice and Primary Health Care (JGE), University of Helsinki; Unit of General Practice (JGE), Helsinki University Central Hospital; and Folkhalsan Research Centre (JGE), Helsinki; and Vasa Central Hospital (JGE), Vasa, Finland; Department of Internal Medicine (DAE), Rush Institute for Health Aging, Rush University Medical Center, Chicago, Illinois; Longitudinal Studies Section (LF), Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland; Brown Foundation Institute of Molecular Medicine (MF), University of Texas Health Science Center at Houston, Houston, Texas; Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging (AH, AGU, CMvD, HT), Leiden, The Netherlands; Research Unit of Molecular Epidemiology (TI), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Neurology (MK-H), Boston University School of Medicine, Boston, Massachusetts; Department of Epidemiology (KK), Mailman School of Public Health, Columbia University, New York, New York; Department of Biostatistics (JMM), Boston University School of Public Health, Boston, Massachusetts; Epidemiology and Public Health (DM, LCP, DJL), Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom; Center for Medical Systems Biology (CMvD), Leiden, The Netherlands; Institute of Biomedical and Clinical Sciences (AMur), Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom; Mental Health Center BavoEuropoort (CLM), and Department of Clinical Genetics (BAO), Erasmus MC, Rotterdam, The Netherlands; Wellcome Trust Sanger Institute (APa), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Institute for Molecular Medicine Finland (APa, EW), University of Helsinki, and Department of Medical Genetics (APa), University of Helsinki and University Central Hospital, Helsinki, Finland; Program in Medical and Population Genetics and Genetics Analysis Platform (APa), The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Department of Psychiatry (BPe), Leiden University Medical Centre, Leiden, and Department of Psychiatry (BPe), University Medical Centre Groningen, Groningen, The Netherlands; Institute of Clinical Chemistry and Laboratory Medicine (APe), University Medicine Greifswald, Greifswald, Germany; Cardiovascular Health Research Unit (BPs), Departments of Medicine, Epidemiology, and Health Services, University of Washington, and Group Health Research Institute (BPs), Group Health Cooperative, Seattle, Washington; Institute of Genetic Epidemiology (RR), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Neurogenomics Division (EMR), Translational Genomics Research Institute, and Banner Alzheimer's Institute (EMR), Phoenix, Arizona; Department of Psychiatry and Psychotherapy (AS, HJG), University Medicine Greifswald, Helios-Hospital, Stralsund, Germany; Laboratory of Behavioral Neuroscience (ABZ), National Institute on Aging, Baltimore, Maryland; Department of Internal Medicine (AGU), Erasmus MC, Rotterdam, The Netherlands; Institute for Community Medicine (HV), University Medicine Greifswald, Germany; Department of Psychiatry (KY), University of California San Francisco, San Francisco, California; Icelandic Heart Association (VG, AVS), Kopavogur, Iceland; Departments of Neurology (KY) and Epidemiology and Biostatistics (KY), University of California San Francisco, San Francisco, California; Laboratory of Epidemiology, Demography and Biometry (TH, LJL), National Institute on Aging, Bethesda, Maryland; Department of Biostatistics (KLL), Boston University School of Public Health, Boston, Massachusetts; Department of Medicine (THM), University of Mississippi Medical Center, Jackson, Mississippi; Department of Medicine (JM), Section of General Internal Medicine, Boston University School of Medicine; Program in Molecular and Genetic Epidemiology (DJH, PK), Harvard School of Public Health; and Brigham and Women's Hospital (GC), Harvard Medical School, Boston, Massachusetts; Department of Epidemiology (ABN), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Medicine (VG, AVS), University of Iceland, Reykjavik, Iceland; Hannover Unified Biobank (TI), Hannover Medical School, Hannover, Germany; College of Medicine (ATer, ARS), Florida State University, Tallahassee, Florida; Genetic Epidemiology Unit (AD, NA, BAO, CMvD), Departments of Epidemiology and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands; and Departments of Neurology and Molecular Human Genetics (JMS), Baylor College of Medicine, Houston, Texas.