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Naphthalene derivatives that selectively inhibit an antigen-specific IgE response in murine lymphocytes
1Department of Biotechnology, Faculty of Engineering, Okayama University, Japan.
Abstract:
When the spleen cells from BALB/c mice that had been immunized twice with TNP-KLH were cultured with the same antigen, the synthesis of anti-TNP IgE as well as anti-TNP IgG was induced. We found that the addition of a naphthalene derivative, (E)-N-(2-methoxy-carbonylphenyl)-8-(2-naphthyl)-5,6-trans-5,6-meth ano-7- octenamide (TEI-1338) or methyl-6,7-dihydroxy-2-naphthylthioacetate (TEI-3332) to this lymphocyte culture system resulted in a marked suppression of anti-TNP IgE response without affecting the corresponding IgG production. These compounds are expected to be a prototype for the drug that can be used for the treatment of IgE-mediated allergic diseases.