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Updated: May 15, 2026

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
Published on: August 18, 2017
Development and application of chiral crown ethers as selectors for chiral separation in high-performance liquid
Man-Jeong Paik1, Jong Seong Kang, Bin-Syuan Huang
1College of Pharmacy, Sunchon National University, Sunchon, Jeonnam, 540-950, Republic of Korea.
Abstract:
Chiral crown ethers have been widely used in the resolution of various chiral compounds containing a primary amino group. Covalently bonded chiral stationary phases derived from (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) were developed in our groups and utilized for the resolution for several types of analytes. By use of NMR spectroscopy, chiral discrimination studies were performed for α-amino acids and their esters using 18-C-6-TA. Here, advances in the development and application of chiral stationary phases and chiral solvating agents using 18-C-6-TA for enantiomer resolution are described in relationship to recent chiral recognition mechanism studies.
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