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Updated: May 15, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
[Expression of MICA/B protein in esophageal cancer and its clinical significance]
Jia-zhuan Mei1, Ji-zhi Zhao, Guang-ying Yang
1Department of Oncology, The People's Hospital of Zhengzhou, Zhengzhou 450003, China. mjzhuan@163.com
Objective:
To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.
Methods:
The expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.
Results:
The positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0% (30/40), and that in the corresponding normal esophageal mucosa was 0 (0/40). Up-regulation of MICA/B expression was found in the esophageal carcinomas. The expression of MICA/B was related with histological grade of the esophageal carcinoma (P = 0.012).
Conclusion:
MICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma.
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