Related Experiment Video
Updated: May 15, 2026
Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
ApoE4 confers better spatial memory than apoE3 in young adult hAPP-Yac/apoE-TR mice
Pierre-Henri Moreau1, Jean-Bastien Bott, Celina Zerbinatti
1Laboratoire d'Imagerie et de Neurosciences Cognitives, UMR 7237 CNRS, Université de Strasbourg, IFR 37, GDR CNRS 2905, 12 rue Goethe, F-67000 Strasbourg, France.
Abstract:
The APOE-ɛ4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-ɛ4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperformed their hAPP-Yac/apoE3-TR counterparts on learning and memory performances in the highly hippocampus-dependent, hidden-platform version of the Morris water maze task. The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-ɛ4 on cognitive functions.
