Related Experiment Video
Updated: May 15, 2026
Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Adherence to rotavirus vaccination quality measures in a commercially insured population
Debra F Eisenberg1, T Gu, G Krishnarajah
1HealthCore, Inc.; Wilmington, DE USA.
Insights
Rotavirus vaccination compliance is low in US infants, with many not completing the recommended vaccine series on schedule. This underutilization persists despite available vaccines and guidelines.
Area of Science:
- Pediatric infectious diseases
- Public health surveillance
- Vaccinology
Background:
- Rotavirus vaccination is recommended for infants to prevent severe gastroenteritis.
- Assessing compliance with vaccination schedules is crucial for public health.
- Previous studies have indicated potential gaps in rotavirus vaccine uptake.
Purpose of the Study:
- To evaluate rotavirus vaccination compliance rates within a large US commercially insured population.
- To assess adherence to specific vaccination guidelines, including those from the Pediatric Information (PI), Advisory Committee on Immunization Practices (ACIP), and Healthcare Effectiveness Data and Information Set (HEDIS).
Main Methods:
- Retrospective analysis of medical and pharmacy claims data from the HealthCore Integrated Research Database.
- Stratification of enrolled children into PI, ACIP, and HEDIS cohorts.
- Exclusion of patients with mixed dosing schedules for rotavirus vaccines (RV5 and RV1).
Main Results:
- A significant percentage of infants (27%) did not receive rotavirus vaccinations.
- Incomplete vaccination series were common, particularly for the RV5 vaccine (24%) compared to RV1 (15%).
- While many completed the series, fewer did so according to the recommended schedule.
Conclusions:
- Rotavirus vaccination remains underutilized among US infants.
- Despite effective vaccines and national recommendations, barriers to timely and complete vaccination persist.
- Further efforts are needed to improve rotavirus vaccine uptake in pediatric populations.
Background:
This retrospective study determined the level of compliance to rotavirus vaccination guidelines within a large, commercially insured US population, as well as compliance with PI, ACIP and HEDIS measures for rotavirus vaccination.
Methods:
Medical and pharmacy claims were obtained from the HealthCore Integrated Research Database. Enrolled children were stratified into PI, ACIP and HEDIS cohorts. The PI cohort was subdivided into RV5 and RV1 cohorts due to the differences in dosing schedules and patients with mixed dosing were excluded from the these two cohorts. Patients identified in the HEDIS cohort were linked to the administering physicians.
Results:
Of 162,614 patients in PI cohort, 27% did not receive rotavirus vaccinations, 24% (RV5) and 15% (RV1) had incomplete doses (p < 0.0001; RV1 vs. RV5). A total of 76% of patients completed RV5 series but not on schedule, 54% completed on schedule. A total of 85% of patients completed the RV1 series at any time, 69% completed on schedule. Among health plans, 53% of patients completed the series, 22% (RV5) and 15% (RV1) had incomplete doses (p < 0.0001). Of 2,086 physicians who treated ≥ 10 patients within the plan (regardless of vaccination status), 78% had > 50% of patients complete, 22% had > 90% of patients completed.
Conclusion:
Despite both two effective rotavirus vaccines and national immunization recommendations, rotavirus vaccination remains underutilized for infants.
Related Concept Videos
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:51Vaccinations
01:30Preventive Healthcare Services
01:18Bacterial Gastroenteritis