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Dimer asymmetry defines α-catenin interactions

Erumbi S Rangarajan1, Tina Izard

  • 1Department of Cancer Biology, Scripps Research Institute, Jupiter, Florida, USA.

Nature Structural & Molecular Biology
|January 8, 2013
PubMed
Summary

Alpha-catenin, a protein crucial for cell junctions, forms an asymmetric dimer. This unique structure explains its varying interactions with F-actin and vinculin, clarifying cell adhesion mechanisms.

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