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09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute kidney injury in scrub typhus
Ravindra Prabhu Attur1, Sujatha Kuppasamy2, Manohar Bairy3
1Department of Nephrology, Kasturba Medical College and Hospital, Manipal, Manipal University, Madhavnagar, Manipal, Udupi District, 576104, Karnataka, India. aravindraprabhu@gmail.com.
Clinical and Experimental Nephrology
|January 8, 2013
Summary
Acute kidney injury (AKI) affects over 23% of scrub typhus patients, often presenting mildly with good recovery. Thrombocytopenia and intensive care needs predict AKI development in scrub typhus.
Area of Science:
- Infectious Diseases
- Nephrology
- Critical Care Medicine
Background:
- Scrub typhus is an infectious disease associated with various organ abnormalities.
- Acute kidney injury (AKI) is a significant complication of scrub typhus.
- Understanding urinary abnormalities and AKI in scrub typhus is crucial for patient management.
Purpose of the Study:
- To investigate the prevalence of urinary abnormalities and AKI in scrub typhus patients.
- To identify predictors of AKI in scrub typhus.
- To assess the severity and outcomes of AKI in scrub typhus.
Main Methods:
- A prospective case record-based study was conducted in South India from 2009-2010.
- Patients diagnosed with scrub typhus were assessed for urinary abnormalities and AKI using RIFLE criteria.
- Univariate and multivariable logistic regression analyses were used to determine AKI predictors.
Main Results:
- Out of 259 scrub typhus patients, 23.2% developed AKI, with all AKI cases showing urinary abnormalities.
- RIFLE criteria indicated Risk, Injury, and Failure in 38.33%, 21.67%, and 40% of AKI patients, respectively.
- Significant AKI predictors included tachycardia, breathlessness, intensive care, mechanical ventilation, thrombocytopenia, and elevated CPK. Intensive care and thrombocytopenia were independent predictors.
Conclusions:
- Scrub typhus should be considered in febrile illnesses with AKI.
- AKI in scrub typhus is typically mild, often non-oliguric, with most patients achieving renal recovery.
- Rhabdomyolysis may contribute to AKI; thrombocytopenia and intensive care are key predictors.
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