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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: May 15, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Neural regeneration.

Melissa M Steward1, Akshayalakshmi Sridhar, Jason S Meyer

  • 1Department of Biology, Indiana University Purdue University, Indianapolis, IN, USA.

Current Topics in Microbiology and Immunology
|January 8, 2013
PubMed
Summary
This summary is machine-generated.

Neural regeneration in humans is limited, but stem cells and cellular reprogramming offer new hope for repairing nerve damage. These advanced methods provide innovative strategies for nervous system repair and treatment.

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
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Published on: January 10, 2018

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Last Updated: May 15, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Biology

Background:

  • Human neural regeneration capacity is limited compared to lower organisms.
  • Nerve cell damage from injury or disease poses significant treatment challenges.
  • Traditional methods for neural repair have shown limited success.

Purpose of the Study:

  • To review current and emerging strategies for neural regeneration.
  • To discuss the potential of stem cells and cellular reprogramming in nerve repair.
  • To highlight advancements in generating patient-specific neuronal cell types.

Main Methods:

  • Review of traditional neural regeneration enhancement techniques.
  • Exploration of adult stem cells from hippocampus and subventricular zone.
  • Investigation of pluripotent stem cells, including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs).
  • Analysis of direct genetic reprogramming of somatic cells to neuronal fate.

Main Results:

  • Stem cells offer a source for replacing damaged neurons due to self-renewal and differentiation capabilities.
  • Pluripotent stem cells provide novel avenues for neural cell replacement.
  • Direct reprogramming bypasses the pluripotent stage, accelerating mature neuronal cell production from patient-specific cells like fibroblasts or blood cells.

Conclusions:

  • Stem cell therapies and cellular reprogramming have revolutionized regenerative biology.
  • These innovative approaches offer potential solutions for nervous system regeneration.
  • Despite remaining challenges, these strategies hold promise for treating neurological injuries and diseases.