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Updated: May 15, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
Cord blood transplantation in aplastic anemia
R Peffault de Latour1, V Rocha, G Socié
1Bone Marrow Transplant Unit, Hôpital Saint Louis-APHP, Université Paris VII, Paris, France. regis.peffaultdelatour@sls.aphp.fr
Abstract:
For patients with inherited BM failure (BMF) or those with acquired BMF who fail immunosuppressive therapy and who lack a suitable alternative donor, the prognosis remains poor. Umbilical cord blood transplantation has extended the availability of hematopoietic stem cell transplantation in the absence of a suitable donor. A recent EBMT study confirmed the feasibility of this treatment and highlighted the fundamental role of the TNC dose (>3.9 × 10(7)/kg TNC/kg) on both engraftment and OS using cord blood as stem cell source in severe aplastic anemia. However, this procedure is still experimental and should be evaluated only through prospective clinical trials.
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