Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bunch-by-bunch position measurement and analysis at PLS-II.

Journal of synchrotron radiation·2016

Same author

Multiple-input nonlinear modelling of cerebral haemodynamics using spontaneous arterial blood pressure, end-tidal CO2 and heart rate measurements.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2016

Same author

Compartmental and Data-Based Modeling of Cerebral Hemodynamics: Linear Analysis.

IEEE access : practical innovations, open solutions·2016

Same author

Model-based physiomarkers of cerebral hemodynamics in patients with mild cognitive impairment.

Medical engineering & physics·2014

Same author

On parsing the neural code in the prefrontal cortex of primates using principal dynamic modes.

Journal of computational neuroscience·2013

Same author

Model-based quantification of cerebral hemodynamics as a physiomarker for Alzheimer's disease?

Annals of biomedical engineering·2013

Search research articles

Related Experiment Video

Updated: May 15, 2026

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Published on: February 17, 2013

Closed-loop dynamic modeling of cerebral hemodynamics.

V Z Marmarelis¹, D C Shin, M E Orme

¹University of Southern California, Los Angeles, CA, USA. vzm@usc.edu

Annals of Biomedical Engineering

|January 8, 2013

Summary

This study introduces a novel nonlinear, closed-loop model to quantify cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity (CVMR) dynamics using non-invasive measurements. The method aims to improve diagnostics for various neurological conditions.

More Related Videos

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

Related Experiment Videos

Last Updated: May 15, 2026

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Published on: February 17, 2013

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

Area of Science:

Neuroscience
Physiology
Biomedical Engineering

Background:

Cerebral hemodynamics are crucial for physiological and clinical understanding.
Cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity (CVMR) are implicated in numerous pathologies like stroke and Alzheimer's disease.
Accurate quantification of cerebral vascular dysfunction is needed for diagnostic advancements.

Purpose of the Study:

To present a novel nonlinear, closed-loop dynamic modeling method.
To quantify the dynamics of CFA and CVMR using practical clinical data.
To enable reliable assessment of cerebral vascular dysfunction.

Main Methods:

Utilized beat-to-beat measurements of mean arterial blood pressure, cerebral blood flow velocity, and end-tidal CO2.
Collected data non-invasively under resting conditions.
Developed a unique nonlinear, closed-loop dynamic model.

Main Results:

The proposed model effectively quantifies CFA and CVMR dynamics.
The nonlinear, closed-loop approach offers a novel perspective on cerebral hemodynamic regulation.
The method is designed for practical clinical application.

Conclusions:

The developed modeling method provides a reliable way to quantify cerebral hemodynamic dynamics.
This approach holds promise for developing new diagnostic tools for cerebrovascular diseases.
Non-invasive, beat-to-beat measurements combined with a nonlinear closed-loop model are effective.