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Updated: May 15, 2026

Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
Published on: January 10, 2011
SAR studies on β-cell K(ATP) channel openers
Jyoti Singh1, Basheerulla Shaik, Vijay K Agrawal
1Department of SHM, Amrapali Institute of Technology & Sciences, Shiksha Nagar, Lamachaur, Haldwani, 263139, Uttara Khand, India.
Abstract:
Recently Balaban has introduced a J-type G index for modeling those properties/activities where not only the "shape" but also size of the graph influences the property/activity of organic compounds acting as drugs. Here, for the first time G index has been used for modeling the pancreatic β-cell K(ATP) channel openers viz R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(substituted phenylaminocarbonylamino)-2H-1-benzopyrans. Modeling technology used in this paper has established that the referred activity is excellently modeled by using G as one of the correlating descriptors. The results are critically discussed using Ridge statistics.
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