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Related Experiment Video

Updated: May 15, 2026

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
13:42

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

Published on: July 17, 2012

A fast protocol for infarct quantification in mice.

Guido Buonincontri1, Carmen Methner, Thomas Krieg

  • 1Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Journal of Magnetic Resonance Imaging : JMRI
|January 8, 2013
PubMed
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This summary is machine-generated.

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This study presents an efficient late gadolinium enhancement (LGE) imaging protocol for assessing myocardial infarction in mouse models. The optimized method accurately measures infarct size, aiding heart disease research.

Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Preclinical Research

Background:

  • Assessing myocardial infarction in mouse models is crucial for understanding heart disease.
  • Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is a key technique for evaluating tissue viability.
  • Existing LGE protocols can be time-consuming, limiting their application in dynamic interventional studies.

Purpose of the Study:

  • To develop and validate an optimized LGE imaging protocol for interventional mouse models of myocardial infarction.
  • To improve the efficiency and accuracy of infarct size measurement in preclinical cardiac research.
  • To provide a robust tool for assessing tissue viability post-myocardial infarction in small animal models.

Main Methods:

  • An efficient sampling scheme utilizing multiple slices within a single heartbeat was employed.
Keywords:
TI optimizationischemialate gadolinium enhancement (LGE)myocardial infarction

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Last Updated: May 15, 2026

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
13:42

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

Published on: July 17, 2012

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice
08:28

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Published on: January 19, 2022

  • Slice packages were interleaved between alternate repetition times (TRs) to enhance signal-to-noise ratio (SNR) efficiency.
  • Saturation effects were optimized to balance image contrast and acquisition speed, achieving whole-heart coverage in 3 minutes.

    • Main Results:

    • The developed protocol yielded high hyperenhancement with excellent contrast-to-noise ratio.
    • Inversion time optimization was found to be unnecessary with this scheme, simplifying the protocol.
    • Measured infarct sizes demonstrated strong correlation with histological validation, confirming accuracy.

    Conclusions:

    • The optimized LGE protocol provides an efficient and accurate tool for infarct size measurement in mouse models of myocardial infarction.
    • This method enhances the assessment of tissue viability in preclinical cardiovascular research.
    • The protocol facilitates improved understanding and evaluation of heart disease interventions in small animal models.