Related Experiment Video

Updated: May 15, 2026

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
05:06

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

Multidrug-resistant acinetobacter infection and their susceptibility patterns in a tertiary care hospital

Kalidas Rit1, Rajdeep Saha

  • 1Department of Microbiology, Institute of Post-Graduate Medical Education and Research, Malda Medical College and Hospital, Kolkata, West Bengal, India.

Nigerian Medical Journal : Journal of the Nigeria Medical Association
|January 8, 2013
PubMed
Abstract

Insights

Antibiotic-resistant Acinetobacter infections, particularly Acinetobacter baumannii, are a significant hospital concern. This study highlights Acinetobacter baumannii

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Antibiotic-resistant Acinetobacter infections pose a major challenge in healthcare settings.
  • Acinetobacter species are opportunistic pathogens causing diverse infections like pneumonia, meningitis, and bacteremia.
  • Multidrug-resistant Acinetobacter infections present significant difficulties in hospitals.

Purpose of the Study:

  • To investigate the distribution and antimicrobial resistance profiles of Acinetobacter species in clinical specimens.
  • To identify the predominant Acinetobacter species causing nosocomial infections.
  • To assess the resistance patterns of Acinetobacter against commonly used antibiotics.

Main Methods:

  • Standard microbiological techniques were employed to analyze clinical specimens from various hospital wards and ICUs.
  • Antimicrobial susceptibility testing was performed using the modified Kirby Bauer disk diffusion method.
  • The Clinical and Laboratory Standards Institute (CLSI) protocol was followed for resistance testing.

Main Results:

  • Acinetobacter baumannii was the most prevalent species (74.02%), followed by A. lowfii (14.2%), A. haemolyticus (7.79%), and A. junii (3.8%).
  • High resistance rates were observed against ceftazidime (74.1%), gentamicin (70.13%), and ofloxacin (42.21%).
  • Lower resistance was noted for imipenem (5.2%), meropenem (9.75%), and piperacillin-tazobactum (18.2%).

Conclusions:

  • Acinetobacter baumannii is frequently associated with urinary tract infections, respiratory tract infections, septicemia, bacteremia, meningitis, and wound infections.
  • Acinetobacter baumannii exhibited greater resistance to multiple antibiotics compared to other nosocomial pathogens in the ICU.
  • The findings underscore the urgent need for effective antimicrobial stewardship and infection control strategies against multidrug-resistant Acinetobacter.
Keywords:
Acinetobacterantibiotic resistancenosocomial infection

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...