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CoCoMac 2.0 and the future of tract-tracing databases
Rembrandt Bakker1, Thomas Wachtler, Markus Diesmann
1Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Nijmegen, Netherlands ; Institute of Neuroscience and Medicine 6, Research Center Jülich Jülich, Germany ; Department Biology II, Ludwig-Maximilians-Universität München Munich, Germany.
Frontiers in Neuroinformatics
|January 8, 2013
Summary
The CoCoMac database was redeveloped to map the macaque monkey brain connectome. This enhanced resource facilitates neuroscientific research by integrating axonal tract-tracing data and comparing it with other connectome projects.
Area of Science:
- Neuroscience
- Computational Biology
- Comparative Neuroanatomy
Background:
- The CoCoMac database compiles results from hundreds of axonal tract-tracing studies in macaque monkeys.
- This data is crucial for constructing the macaque macro-connectome, aiding in understanding brain wiring.
- Previous versions required enhancements for broader accessibility and functionality.
Purpose of the Study:
- To discuss the redevelopment of the CoCoMac database and its new features.
- To compare CoCoMac with six other connectome-related projects, highlighting its unique contributions.
- To explore the future of neuronal tracing in brain connectome construction.
Main Methods:
- Redevelopment of the CoCoMac database with enhanced features.
- Comparison of CoCoMac with six diverse connectome projects (rodent data resources, 3D viewers, data management systems, simulation software).
- Implementation of a new search wizard and on-demand connectivity matrix computation.
Main Results:
- The second edition of CoCoMac offers significant improvements, including a user-friendly search wizard.
- Users can now generate custom connectivity matrices in selected nomenclatures.
- A preview of a new community-driven data entry system is introduced.
Conclusions:
- The enhanced CoCoMac database provides a more powerful tool for macaque brain connectome research.
- The study highlights advancements in connectomics, including human connectome projects and novel imaging techniques.
- Neuronal tracing remains a key method, but its future role alongside new technologies is considered.
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