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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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The neuropsychological profile of children with Diffuse Intrinsic Pontine Glioma (DIPG) before and after radiation therapy: A prospective longitudinal study.

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Updated: May 15, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Diffuse intrinsic pontine glioma: poised for progress.

Katherine E Warren1

  • 1Pediatric Neuro-Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health Bethesda, MD, USA.

Frontiers in Oncology
|January 8, 2013
PubMed
Summary

Diffuse intrinsic pontine gliomas (DIPG) are difficult pediatric brain tumors. Recent studies reveal DIPGs are a distinct entity, paving the way for targeted treatments.

Keywords:
DIPGbrainstemdiffusegliomaintrinsicpediatricponspontine

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Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Cancer Biology

Background:

  • Diffuse intrinsic pontine gliomas (DIPG) are aggressive pediatric brain tumors.
  • Current treatments including surgery, radiation, and chemotherapy have shown limited efficacy.
  • DIPG diagnosis relies on imaging, with tissue biopsy not standard practice.

Purpose of the Study:

  • To review the current understanding of DIPG biology and treatment challenges.
  • To highlight recent findings that establish DIPGs as a unique tumor entity.
  • To explore future directions for DIPG-specific therapeutic development.

Main Methods:

  • Literature review of current DIPG research.
  • Analysis of recent pivotal studies on DIPG biology.
  • Synthesis of information on treatment obstacles and therapeutic opportunities.

Main Results:

  • DIPGs have historically been treated based on adult high-grade glioma paradigms.
  • Emerging evidence strongly suggests DIPGs are a distinct biological entity.
  • This distinct classification opens new avenues for targeted research and treatment.

Conclusions:

  • Recognizing DIPGs as a unique entity is crucial for advancing treatment strategies.
  • Further biological investigation is essential for developing effective, DIPG-specific therapies.
  • Overcoming treatment challenges requires a shift from generalized glioma approaches to DIPG-focused research.