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Updated: May 15, 2026
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
A new three-dimensional analysis of asymmetry for patients with craniofacial syndromes
R M Yáñez-Vico1, A Iglesias-Linares, D Torres-Lagares
1Department of Stomatology, School of Dentistry, University of Seville, Seville, Spain.
Objecives:
The use of three-dimensional computed tomography (3D-CT) analyses represents a substantial improvement in planning treatment. The aim of this study is to introduce a new three-dimensional (3D) analysis of clinical value for evaluating asymmetry in cases of craniofacial syndrome.
Subjects And Methods:
Virtual 3D models were reconstructed from CT images of 62 normal subjects (35 males and 27 females), more than 18 years old. Measurements of asymmetrical skeletal and dentoalveolar relationships were evaluated and standardized data obtained. The feasibility of the new 3D craniofacial analysis was then evaluated on one patient with severe maxillomandibular asymmetry in the form of hemifacial microsomia.
Results:
Standardized 3D data from the analysis were obtained and classified into 6 maxillary measurements, eight mandibular measurements and seven dentoalveolar process measurements. No significant differences were found between males and females (U-Mann-Whitney test, P > 0.05). Useful data of clinical value was provided for planning orthodontic and surgical treatment of asymmetries, as well as a diagnostic chart.
Conclusion:
This method is useful for the clinical evaluation of asymmetry in craniofacial syndromes. The use of 3D analysis facilitates surgical and orthodontic treatment planning.
