Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress-dependent erosion and post-failure morphology at soil-structure interface: insights from spatially zoned dyed soil.

Scientific reports·2026
Same author

Low-dose ionizing radiation drives thyroid carcinogenesis via VPS53 enhanced EGFR Re-recycling.

Free radical biology & medicine·2026
Same author

m<sup>6</sup>A-modified ATF4 regulates glucose/lipid metabolism via the Sestrin2/GSK3β axis to alleviate myocardial ischemia-reperfusion injury.

Journal of cardiothoracic surgery·2026
Same author

ENPP2 Dysregulation Defines a Candidate Biomarker Axis Coupling Tumor-Intrinsic cAMP Signaling to Macrophage Polarization in Hepatocellular Carcinoma.

Human mutation·2026
Same author

Corrigendum to "MLN4924 suppresses the BRCA1 complex and synergizes with PARP1 inhibition in NSCLC cells" [Biochem. Biophys. Res. Commun. 483 (1) (2017) 223-229].

Biochemical and biophysical research communications·2026
Same author

AI-driven digital twins for bone tumors: personalizing immunoradiotherapy and drug-based radiosensitization.

Frontiers in pharmacology·2026

Related Experiment Video

Updated: May 15, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Radon-induced alterations in micro-RNA expression profiles in transformed BEAS2B cells.

Feng-Mei Cui1, Jian-Xiang Li, Qiu Chen

  • 1Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing, China.

Journal of Toxicology and Environmental Health. Part A
|January 9, 2013
PubMed
Summary

Radon exposure increases lung cancer risk. This study reveals radon-induced malignant transformation in lung cells involves altered microRNA expression and resistance to apoptosis, offering insights into cancer mechanisms.

More Related Videos

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Related Experiment Videos

Last Updated: May 15, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Area of Science:

  • Environmental Health
  • Molecular Biology
  • Cancer Research

Background:

  • Radon is a known carcinogen responsible for 10% of global lung cancers.
  • The precise molecular mechanisms driving radon-induced lung cancer remain largely unknown.

Purpose of the Study:

  • To investigate the molecular mechanisms of malignant transformation induced by radon exposure in lung cells.
  • To identify specific microRNA (miRNA) expression profiles associated with radon-induced cellular changes.

Main Methods:

  • BEAS2B lung cells were exposed to radon gas, with subsequent subculturing to assess long-term effects.
  • Assessed molecular changes including apoptosis, seroresistance, and miRNA expression profiles.
  • Utilized functional annotation of miRNA target genes to understand their roles in malignant transformation.

Main Results:

  • Radon-exposed cells (Rn5-20) exhibited increased seroresistance, enhanced colony formation, and resistance to apoptosis.
  • Significant differential expression of several miRNAs (e.g., hsa-miR-483-3p, hsa-miR-494, hsa-miR-125b) was observed.
  • Functional annotation linked these miRNAs to cell proliferation, differentiation, and adhesion pathways.

Conclusions:

  • Radon exposure induces malignant transformation in lung cells through alterations in miRNA expression.
  • Key signaling pathways like MAPK, Wnt, ROS, and NF-κB are implicated in radon-induced carcinogenesis.
  • Understanding these miRNA-driven mechanisms is crucial for developing strategies against radon-induced lung cancer.