Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Application of the 2024 McDonald Criteria in Individuals With Nonspecific Symptoms or Incidental Imaging Findings in a Multicenter Study.

Neurology·2026

Same author

Progressive disability but survival advantage in anti-Hu/ANNA1 paraneoplastic neurological syndromes.

Journal of neurology·2026

Same author

Disease-modifying treatment preferences and decision-making in a multiple sclerosis randomized and observational clinical trial (DELIVER-MS).

Multiple sclerosis (Houndmills, Basingstoke, England)·2026

Same author

Effect of Botulinum Toxin Injection Intervals on the Irreversibility of Targeted Muscle Paralysis: An Electromyographic Study.

Aesthetic surgery journal·2026

Same author

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants.

Annals of clinical and translational neurology·2026

Same author

Paramagnetic rim lesions on 7T MRI after autologous hematopoietic cell transplantation.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026

Search research articles

Related Experiment Video

Updated: May 15, 2026

Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus

Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus

Published on: July 10, 2011

Mesenchymal stem cell transplantation in multiple sclerosis.

Jeffrey A Cohen¹

¹Mellen Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA.

Journal of the Neurological Sciences

|January 9, 2013

Summary

Mesenchymal stem cells (MSCs) show promise for treating multiple sclerosis (MS) due to their repair and anti-inflammatory properties. Early studies suggest MSC transplantation is safe and well-tolerated in MS patients.

Keywords:

BM CNS EAE EDSS Expanded Disability Status Scale FBS HGF IBMIR IFN IL IV Immunomodulation MOG MRI MS MSC Multiple sclerosis Neuroprotection Regeneration Stem cell transplantation TNFα bone marrow central nervous system experimental autoimmune encephalomyelitis fetal bovine serum hMSC-CM hepatocyte growth factor human mesenchymal stem cell conditioned medium instant blood-mediated inflammatory reaction interferon interleukin intravenous magnetic resonance imaging mesenchymal stem cell multiple sclerosis myelin oligodendrocyte glycoprotein tumor necrosis factor-alpha

More Related Videos

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Related Experiment Videos

Last Updated: May 15, 2026

Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus

Surgical Transplantation of Mouse Neural Stem Cells into the Spinal Cords of Mice Infected with Neurotropic Mouse Hepatitis Virus

Published on: July 10, 2011

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Area of Science:

Stem Cell Biology
Neuroimmunology
Regenerative Medicine

Background:

Mesenchymal stem cells (MSCs) are multipotent stem cells with immunomodulatory and tissue-repairing capabilities.
MSCs share similarities with pericytes and can differentiate into mesodermal lineages.
Their properties make them a potential therapeutic for inflammatory and degenerative conditions like multiple sclerosis (MS).

Purpose of the Study:

To evaluate the safety and tolerability of autologous, culture-expanded bone marrow-derived MSC transplantation in patients with MS.
To explore the potential of MSCs as a therapeutic strategy for MS.

Main Methods:

Formal studies involving autologous, culture-expanded, bone marrow-derived MSC transplantation in MS patients.
Monitoring for safety concerns and overall tolerability of the procedure.

Main Results:

Published experience with MSC transplantation in MS is modest but preliminary results are promising.
The procedure has been well-tolerated to date, with no significant safety concerns reported.
Initiation of formal studies by multiple research groups, including the authors.

Conclusions:

MSC transplantation is a potentially safe and well-tolerated therapeutic approach for MS.
Further rigorous studies are needed to definitively assess the efficacy of MSCs in MS treatment.
Addressing technical challenges will be crucial for future clinical applications of MSCs in MS.