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Postoperative analgesia in children after propofol versus sevoflurane anesthesia
Antigona Hasani1, Agreta Gecaj-Gashi, Sadik Llullaku
1Department of Anesthesiology and Reanimation, University Clinical Centre of Kosova, Prishtina, Kosovo. antigona.hasani@gmail.com
Insights
Propofol anesthesia in children undergoing hernia repair resulted in significantly less postoperative pain compared to sevoflurane. This study highlights propofol as a potentially better option for pediatric pain management post-surgery.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Pain Management
Background:
- Effective postoperative analgesia is crucial, particularly in pediatric patients.
- Current anesthetic techniques present challenges in managing post-surgical pain in children.
Purpose of the Study:
- To compare the incidence of postoperative pain in children anesthetized with propofol versus sevoflurane.
- To evaluate the impact of anesthetic agents on pain scores and recovery time in pediatric surgical patients.
Main Methods:
- A randomized, prospective, double-blind study was conducted with 88 children (aged 3-6 years) undergoing hernia repair.
- Anesthesia was maintained using either propofol or sevoflurane, with standardized analgesia protocols including paracetamol and bupivacaine.
- Pain was assessed using the Faces Pain Scale (FPS) 2 hours postoperatively, with recovery time and adverse events as secondary outcomes.
Main Results:
- Children receiving propofol anesthesia exhibited significantly lower postoperative pain scores (1.2 ± 0.6) compared to those receiving sevoflurane (3.4 ± 1.5).
- The incidence of postoperative pain was substantially higher in the sevoflurane group (24.3%) than in the propofol group (4.5%).
- Recovery time was significantly shorter in the sevoflurane group (10.1 ± 1.3 minutes) compared to the propofol group (16.5 ± 5.4 minutes).
Conclusions:
- Propofol anesthesia is associated with a significantly lower incidence of postoperative pain in children compared to sevoflurane.
- These findings suggest propofol may be a preferred anesthetic agent for managing postoperative pain in pediatric surgical patients.
- While sevoflurane offered faster recovery, the increased pain incidence warrants consideration in anesthetic choices for pediatric procedures.
Objective:
Postoperative analgesia remains a problem, especially in pediatric patients. We hypothesize that patients anesthetized with sevoflurane have more postoperative pain than with propofol.
Design:
Randomized, prospective, double-blind study.
Setting:
University teaching hospital.
Subjects:
The subjects were 88 premedicated children, aged 3-6 years, and American Society of Anesthesiologists (ASA) Physical Status I or II.
Interventions:
Subjectsunderwent hernia repair surgery.
Methods:
Anesthesia was maintained with propofol (group P, N = 46) or sevoflurane (group S, N = 42) and fentanyl was administered during surgery. All children before surgical incision received 40 mg/kg paracetamol, rectally. Prior to wound closure, the margins were infiltrated with 0.5% bupivacaine.
Outcome Measures:
The primary outcome was pain score assessed by Faces Pain Scale (FPS) 2 hours postoperatively. The secondary outcomes included recovery time and adverse events within the first 2 hours.
Results:
Group S had a significantly higher proportion of patients who exhibited postoperative pain than group P (24.3% vs 4.5%, respectively; P < 0.05). FPS score in group P was 1.2 ± 0.6, compared with 3.4 ± 1.5 in group S (P < 0.001). Mean recovery time in group S was significantly shorter than the corresponding mean for group P (10.1 ± 1.3 vs 16.5 ± 5.4 minutes, respectively; P < 0.001).
Conclusion:
In children, anesthesia maintenance with propofol was associated with a significantly lower incidence of postoperative pain than with sevoflurane.
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