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Updated: Aug 13, 2026

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Pseudomembranous enterocolitis--a potentially lethal disease

A A Azmy1, P A Raine, D G Young

  • 1Department of Paediatric Surgery, Royal Hospital for Sick Children, Glasgow, Scotland.

Journal of Pediatric Surgery
|April 1, 1990
PubMed

Insights

Pseudomembranous enterocolitis in children is a severe condition often linked to antibiotic use and other illnesses. Aggressive medical and surgical intervention is crucial for managing this potentially fatal disease.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases

Background:

  • Pseudomembranous enterocolitis (PMC) is a serious intestinal condition.
  • PMC is often associated with prior antibiotic exposure.
  • Comorbidities can increase the risk of developing PMC.

Observation:

  • This report details nine pediatric cases of pseudomembranous enterocolitis.
  • Five of the nine children in the study died from the condition.
  • Six patients had a history of antibiotic therapy.
  • Eight patients had other underlying diseases contributing to PMC.

Findings:

  • Pseudomembranous enterocolitis presents a significant mortality risk in children.
  • Antibiotic use and concurrent medical conditions are key risk factors.
  • Early recognition and prompt, aggressive management are vital for improving outcomes.

Implications:

  • Increased awareness of PMC is needed among healthcare professionals.
  • Aggressive medical and surgical strategies are essential for treating pediatric PMC.
  • Further research into risk factors and preventative measures for PMC is warranted.

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